• Corpus ID: 16656144

N-sulfonylpyrimidine derivatives and hyperthermia treatment of anaplastic mammary carcinoma in vivo.

@article{Pavlak2010NsulfonylpyrimidineDA,
  title={N-sulfonylpyrimidine derivatives and hyperthermia treatment of anaplastic mammary carcinoma in vivo.},
  author={Marina Pavlak and Marko Rada{\vc}i{\'c} and Ranko Stojkovi{\'c} and Biserka Žini{\'c}},
  journal={Veterinarski Arhiv},
  year={2010},
  volume={80},
  pages={311-321}
}
The aim of this study was to investigate in vivo antitumor activity of newly synthesized N-sulfonylpyrimidine derivatives applied as a single agent and in combination with hyperthermia (43 oC/60 min). Antitumor activity was examined for: 1-(p-toluenesulfonyl)cytosine (4H), 1-(p-toluenesulfonyl)cytosine hydrochloride (4HxHCl), complex (Zn(II) [1-(p-toluenesulfonyl)cytosine]2) (4K) and 5-bromo-1-(methanesulfonyl)uracil (8H). In the study was used transplantable anaplastic mammary carcinoma (AMCa… 

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SHOWING 1-10 OF 45 REFERENCES
Antitumor activity of novel N-sulfonylpyrimidine derivatives on the growth of anaplastic mammary carcinoma in vivo
TLDR
It has been found that N-1-sulfonylcytosine derivatives have strong antitumor activity against mouse mammary carcinoma which is a good reason for further research of these compounds both in experimental and preclinical studies.
Antineoplastic activity of novel N-1-sulfonypyrimidine derivatives.
TLDR
It can be concluded that novel N-1-sulfonylpyrimidine derivatives are promising antitumor agents with a strong antiproliferative activity and an ability to induce apoptosis in treated tumor cells.
Synthesis, spectroscopic characterization and biological activity of N-1-sulfonylcytosine derivatives
TLDR
MTT- cytotoxicity screens in human tissue culture cell lines showed that both N-1-Sulfonylcytosine derivatives demonstrated antiproliferative activity in the different histological types of tumors.
Cell killing of melanoma B16 in vivo by hyperthermia and cytotoxins
  • R. Stojković, M. Radačić
  • Medicine, Biology
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 2002
TLDR
Investigation of antitumour activity of cisplatin, dacarbasine, cyclophosphamide and a new compound from the nitrosourea group - acetamido-CNU - applied with or without local hyperthermia found therapeutic results were significantly better than results achieved by combining cisPlatin and hyperThermia or dacARbasine and hyper thermalmia.
Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo
TLDR
Investigating in vivo toxic effects and finding acute toxic doses of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine showed that derivatives 1, 2, 7, 12 and 13 cause less toxicity than derivatives 4, 6, 8 and 9.
Effects of thermochemotherapy [1-hexylcarbamoyl-5-fluorouracil (HCFU) combined with hyperthermia]: a basic study on the most effective timing and sequence in vivo.
TLDR
An enhanced antitumor effect and a significant increase in 5-FU concentration in tumor tissue were observed in post-heated groups of mice as compared with pre- heated groups and groups given HCFU alone.
SYNTHESIS AND ANTITUMOR ACTIVITY OF 5-BROMO-1-MESYLURACIL
TLDR
The purpose of this study was to elucidate the effects of BMsU on the biosynthetic activity of tumor cell enzymes involved in DNA, RNA and protein syntheses, and in de novo and salvage pyrimidine and purine syntheses.
The antitumor effect of hyperthermia combined with fluorouracil and its analogues.
TLDR
Hyperthermia combined with FT-207 orFT-207 + uracil is considered to be effective and synergistic effect for the inhibition of growth of both tumors which was not observed with 5-FU.
Atypical cytostatic mechanism of N-1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis
TLDR
The computational results taken together with cell cycle perturbation and apoptosis analysis of the cell lines point to an unusual mechanism of cytostatic action, possibly a combination of nucleic acid antimetabolite activity and a novel molecular mechanism.
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