N-substituted hydroxyureas as urease inhibitors.

@article{Uesato2002NsubstitutedHA,
  title={N-substituted hydroxyureas as urease inhibitors.},
  author={Shinichi Uesato and Yuichiro Hashimoto and Masaru Nishino and Yasuo Nagaoka and Hiroshi Kuwajima},
  journal={Chemical & pharmaceutical bulletin},
  year={2002},
  volume={50 9},
  pages={1280-2}
}
In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme. 

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