N-substituent effect on the cis-trans geometry of nine-membered lactams.

@article{Yamada2002NsubstituentEO,
  title={N-substituent effect on the cis-trans geometry of nine-membered lactams.},
  author={Shinji Yamada and Akie Homma},
  journal={Chemical communications},
  year={2002},
  volume={22},
  pages={2656-7}
}
The cis-trans geometry of a nine-membered lactam significantly depends on the N-substituents; N-acyl-1-aza-2-cyclononanones (1a-c) exist as cis form; in contrast, N-Z- 1-aza-2-cyclononanone (1d) exists as trans form both in the crystal and in solution. 

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