N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.

@article{Paquette1993NrasMA,
  title={N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.},
  author={Ronald L. Paquette and Elliot M. Landaw and Robert V. Pierre and James P Kahan and Michael Luebbert and Oscar Lazcano and Giorgis Isaac and Frank Mccormick and H Phillip Koeffler},
  journal={Blood},
  year={1993},
  volume={82 2},
  pages={590-9}
}
To evaluate the clinical significance of N-ras mutations in the myelodysplastic syndrome (MDS) archival bone marrow samples from 252 patients were studied for the presence of N-ras exon I mutations using polymerase chain reaction amplification and differential oligonucleotide hybridization. Subsequently, clinical information about these patients was obtained and analyzed. Of 220 evaluable patients, 20 (9%) had point mutation of N-ras involving codon 12. Individuals with N-ras mutation had a… CONTINUE READING