N-phenylethyl amitriptyline in rat sciatic nerve blockade.

  title={N-phenylethyl amitriptyline in rat sciatic nerve blockade.},
  author={Peter Gerner and Mustafa G. Mujtaba and Mohammed Rajik Khan and Yukari Sudoh and Kamen V. Vlassakov and Douglas C. Anthony and G. K. Wang},
  volume={96 6},
BACKGROUND The antidepressant amitriptyline is commonly used orally for the treatment of chronic pain, particularly neuropathic pain, which is thought to be caused by high-frequency ectopic discharge. Among its many properties, amitriptyline is a potent Na(+) channel blocker in vitro, has local anesthetic properties in vivo, and confers additional blockade at high stimulus-discharge rates (use-dependent blockade). As with other drug modifications, adding a phenylethyl group to obtain a… CONTINUE READING