N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism

@article{Okine2016NpalmitoylethanolamideIT,
  title={N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism},
  author={Bright N Okine and Manish K. Madasu and Fiona McGowan and Charles Prendergast and Jessica C. Gaspar and Brendan Harhen and Michelle Roche and David P. Finn},
  journal={PAIN},
  year={2016},
  volume={157},
  pages={2687–2696}
}
Abstract The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA administration into the anterior cingulate cortex (ACC), an important brain region linked with cognitive and affective modulation of pain, on formalin-evoked nociceptive behaviour in rats. Potential involvement of peroxisome proliferator-activated receptor isoforms (PPAR… 
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