N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.

@article{Rimmerman2008NpalmitoylGA,
  title={N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.},
  author={Neta Rimmerman and Heather B. Bradshaw and H. Velocity Hughes and Jay Shih-Chieh Chen and Sherry Shu-Jung Hu and Douglas McHugh and Eivind Vefring and Jan Anker Jahnsen and Edgar L. Thompson and Kim R Masuda and Benjamin F Cravatt and Sumner H. Burstein and Michael R. Vasko and A. Fe Lorenzo Prieto and David K. O'Dell and Jennifer M. Walker},
  journal={Molecular pharmacology},
  year={2008},
  volume={74 1},
  pages={
          213-24
        }
}
N-arachidonoyl glycine is an endogenous arachidonoyl amide that activates the orphan G protein-coupled receptor (GPCR) GPR18 in a pertussis toxin (PTX)-sensitive manner and produces antinociceptive and antiinflammatory effects. It is produced by direct conjugation of arachidonic acid to glycine and by oxidative metabolism of the endocannabinoid anandamide. Based on the presence of enzymes that conjugate fatty acids with glycine and the high abundance of palmitic acid in the brain, we… CONTINUE READING

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