N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.

@article{Boucher1994NOA,
  title={N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.},
  author={Jean Luc Boucher and Julien Custot and Sandrine Vadon and Marcel Delaforge and Michel Lepoivre and J. P. Tenu and Ayeko{\'e} Yapo and Daniel Mansuy},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={203 3},
  pages={
          1614-21
        }
}
N omega-Hydroxy-L-arginine (L-NOHA) is a potent inhibitor of the hydrolysis of L-arginine (L-Arg) to L-ornithine (L-Orn) catalyzed by purified bovine liver arginase (BLA). It appears as one of the most powerful arginase inhibitors reported so far (Ki = 150 microM). The other products of NO synthase are either without effect (NO2-, NO3-) or much weaker inhibitors (L-citrulline (L-Cit) and NO) of BLA. Products derived from a possible hydrolysis of L-Arg (L-Orn and urea) or of L-NOHA (L-Cit… CONTINUE READING
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