N-nitroso compounds induce changes in carcinogen-metabolizing enzymes.

  title={N-nitroso compounds induce changes in carcinogen-metabolizing enzymes.},
  author={Salah A Sheweita and Mostafa Mostafa},
  journal={Cancer letters},
  volume={106 2},
The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. The present study shows the influence of N-nitroso compounds on the activities of the above-mentioned enzymes. Single-dose treatment (20 mg/kg body weight) of male mice with… CONTINUE READING