N-n-propyl-norapomorphine: An extremely potent stimulant of dopamine autoreceptors

  title={N-n-propyl-norapomorphine: An extremely potent stimulant of dopamine autoreceptors},
  author={Antonio Argiolas and Giampaolo Mereu and Gino Serra and M. R. Melis and Fabio Fadda and Gian Luigi Gessa},
  journal={Brain Research},
Dopamine agonist treatment of schizophrenia with N-propylnorapomorphine.
Observations suggest a rapid-onset tolerance phenomenon of psychosis to N-propylnorapomorphine and are consistent with results from preclinical experiments, and support the idea that the acute antipsychotic response of DA agonists is mediated by the DA autoreceptor.
Behavioral effects of apomorphine isomers in the rat: Selective locomotor-inhibitory effects of S(+)N-n-propylnorapomorphine
The results suggest that S(+)NPA or its congeners and analogs may have selective antidopaminergic actions in limbic rather than striatal areas of mammalian brain.


Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones.
It is proposed that systemically administered d-amphet-amine selectively depresses the firing rate of dopamine-containing cells in the substantia nigra zona compacta and adjacent ventral tegmental area of the rat midbrain and that these drugs also slow dopamine cells.
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.
Neostriatal 3,4-dihydroxyphenylacetic acid was inceased by chlorpromazine, decreaed by amphetamine and unchanged by promethazine, thus paralleling the effects of these drugs on dopaminergic unit activity, compatible with the neuronal feedback hypothesis.
Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists.
The responses of dopamine cells in the substantia nigra to iontophoretically administered dopamine and intravenous apomorphine were compared to the responses of spontaneously active neurons in the
Midification of tardive dyskinesia and spasmodic torticollis by apomorphine. Possible role of dopamine autoreceptors.
  • E. Tolosa
  • Psychology, Medicine
    Archives of neurology
  • 1978
The results of this study suggest that direct dopamine agonists may be used clinically to attenuate CNS dopaminergic transmission, especially when use of antidopminergic drugs such as the nuroleptics is contraindicated, as in the case of tardive dyskinesia.
Evidence for dopamine receptors mediating sedation in the mouse brain
PomorPHINE and L-dopa have a biphasic action on behaviour; in low doses they decrease motor activity, while in higher doses they cause hyper-motility and sterotypy.
Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar Purkinje cells.
  • G. Siggins, J. Schultz
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1979
Electrophysiological evidence for reciprocal adaptive changes in NE sensitivity is provided, supporting results of biochemical studies.