N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth

@article{Hatzi2002NmycOO,
  title={N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth},
  author={Elissavet G. Hatzi and Carol Murphy and Andreas Zoephel and Heidi Rasmussen and Lucia Morbidelli and Horst Ahorn and Keita Kunisada and Ulrike Tontsch and Michael Klenk and Keiko Yamauchi-Takihara and Marina Ziche and Einar K. Rofstad and Lothar L Schweigerer and Theodore Fotsis},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={3552-3561}
}
Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies. Tumor angiogenesis appears to be governed by alterations of tumor suppressor or oncogenes operant in a broad range of tumors. We have addressed this issue in neuroblastoma, a malignancy characterized by the near-exclusive amplification and overexpression of the N-Myc oncogene. Here, we report that N-Myc overexpression results in down-regulation of interleukin-6 (IL-6) and that IL-6 is an… CONTINUE READING
28 Citations
11 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 11 references

Eur

  • T Fotsis, S Breit, +4 authors L. Schweigerer
  • J. Biochem., 263, 757 ± 764.
  • 1999
Highly Influential
7 Excerpts

Cardiovasc

  • H Matsui, Y Ihara, +4 authors K. Yamauchi-Takihara
  • Res., 42, 104 ± 112.
  • 1999
2 Excerpts

Biochem

  • PC Heinrich, I Behrmann, G Muller-Newen, F Schaper, L. Graeve
  • J., 334, 297 ± 314.
  • 1998
1 Excerpt

Int

  • T Danielsen, Rofstad EK.
  • J. Cancer, 76, 836 ± 841.
  • 1998

J

  • M Ziche, L Morbidelli, +4 authors R. Bicknell
  • Clin. Invest., 99, 2625 ± 2634. Oncogene
  • 1997

Trends Biochem

  • C Grandori, Eisenman RN.
  • Sci., 22, 177 ± 181.
  • 1997

Adv

  • N Bouck, V Stellmach, SC. Hsu
  • Cancer Res., 69, 135 ± 174.
  • 1996
2 Excerpts

Dev

  • LA Megeney, RL Perry, JE LeCouter, MA. Rudnicki
  • Genet., 19, 139 ± 145.
  • 1996
3 Excerpts

Br

  • Y Ohe, ER Podack, +8 authors N. Saijon
  • J. Cancer, 67, 939 ± 944.
  • 1993
1 Excerpt

Mol

  • A Ray, KS LaForge, PB. Sehgal
  • Cell. Biol., 10, 5736 ± 5746.
  • 1990

Similar Papers

Loading similar papers…