N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis

@article{Liu2012NmycDR,
  title={N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis},
  author={W. Liu and F. Xing and M. Iiizumi-Gairani and H. Okuda and M. Watabe and S. K. Pai and P. R. Pandey and S. Hirota and A. Kobayashi and Y. Mo and K. Fukuda and Y. Li and K. Watabe},
  journal={EMBO Molecular Medicine},
  year={2012},
  volume={4},
  pages={93 - 108}
}
Wnt signalling has pivotal roles in tumour progression and metastasis; however, the exact molecular mechanism of Wnt signalling in the metastatic process is as yet poorly defined. Here we demonstrate that the tumour metastasis suppressor gene, NDRG1, interacts with the Wnt receptor, LRP6, followed by blocking of the Wnt signalling, and therefore, orchestrates a cellular network that impairs the metastatic progression of tumour cells. Importantly, restoring NDRG1 expression by a small molecule… Expand
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