N-methyl-d-aspartate receptor-mediated, prolonged afterdischarges of CA1 pyramidal cells following transient cerebral ischemia in the rat hippocampus in vivo

@article{Miyazaki1994NmethyldaspartateRP,
  title={N-methyl-d-aspartate receptor-mediated, prolonged afterdischarges of CA1 pyramidal cells following transient cerebral ischemia in the rat hippocampus in vivo},
  author={Shuhei Miyazaki and Yoichi Katayama and Makoto Furuichi and Tsuneo Kano and Takashi Tsubokawa},
  journal={Brain Research},
  year={1994},
  volume={657},
  pages={325-329}
}
We previously reported the post-ischemic potentiation (PIP) of synaptic efficacy in hippocampal Schaffer collateral/CA1 responses of the rat beginning at 6-8 h following 12 min transient cerebral ischemia in vivo. The present study demonstrated that repetitive stimulation with a relatively low frequency (5 Hz, 6 s), which produced short-lasting afterdischarges (ADs; duration, 4.49 +/- 4.26 s; n = 7) in sham-controls, resulted in prolonged ADs (duration, 26.33 +/- 12.63 s; n = 6; P < 0.001) at… CONTINUE READING

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