N-methyl-d-aspartate enhancement of phasic responses in primate neocortex

  title={N-methyl-d-aspartate enhancement of phasic responses in primate neocortex},
  author={Charles E. Schroeder and Daniel C. Javitt and Mitchell Steinschneider and Ashesh D. Mehta and Syndee J Givre and Herbert G. Vaughan and Joseph C. Arezzo},
  journal={Experimental Brain Research},
 In area 17 of the awake macaque, disinhibition by blockade of GABAA receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-d-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using… CONTINUE READING
14 Citations
25 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 25 references

Role of cortical N - methyl - D - aspartate receptors in deviance detection and working memory : implications for schizophre

  • DC Javitt, M Steinschneider, CE Schroeder, JC Arezzo
  • Proc Natl Acad Sci USA
  • 1996

Temporal and spatial properties of local circuits in neocortex

  • AM Thompson, J Deuchars
  • Trends Neurosci
  • 1994

Epilepsy , role of NMDA receptors

  • M Avoli
  • 1993

The role of NMDA receptors in information transmission

  • NW Daw, Stein PGS, K Fox
  • Annu Rev Neurosci
  • 1993

Laminar analysis of focal paroxysmal discharge in neocortex

  • CE Schroeder, M Steinschneider, DC Javitt, SJ Givre, N Peterson, J Arezzo
  • Electroencephalogr Clin Neurophysiol
  • 1992

Similar Papers

Loading similar papers…