N-methyl-D-aspartate subunit expression during mouse development altered by in utero alcohol exposure.

@article{Toso2005NmethylDaspartateSE,
  title={N-methyl-D-aspartate subunit expression during mouse development altered by in utero alcohol exposure.},
  author={Laura Toso and Sarah H. Poggi and Daniel T Abebe and Robin Roberson and Veronica Dunlap and Jane Hyeon Park and Catherine Y. Spong},
  journal={American journal of obstetrics and gynecology},
  year={2005},
  volume={193 4},
  pages={1534-9}
}
OBJECTIVE Alcohol-related neurodevelopmental disorders are contributors to long-term learning disabilities. By using a model for fetal alcohol syndrome, we have shown that prenatal alcohol exposure results in adult learning deficits of unknown mechanisms. In the developing hippocampus, the N-methyl-D-aspartate (NMDA) receptor subunit NR2B triggers long-term potentiation, fundamental to learning and memory; this is supplemented by the less plastic NR2A subunit in the adult. To understand the… CONTINUE READING
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