N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery.

@article{Patierno2005NmethylDaspartateRM,
  title={N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery.},
  author={Simona Patierno and Wubanche Zellalem and Anthony D. Ho and Christopher G. Parsons and K C Kent Lloyd and Marcello Tonini and Catia Sternini},
  journal={Gastroenterology},
  year={2005},
  volume={128 7},
  pages={2009-19}
}
BACKGROUND & AIMS We tested the hypothesis that N-methyl-D-aspartate (NMDA) receptors mediate surgery-induced opioid release in enteric neurons. METHODS We used mu opioid receptor (muOR) internalization as a measure of opioid release with immunohistochemistry and confocal microscopy. MuOR internalization was quantified in enteric neurons from nondenervated and denervated ileal segments of guinea pig after abdominal laparotomy with and without pretreatment with NMDA-receptor antagonists acting… CONTINUE READING
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