N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers.

@article{Decker2010NmethylDaspartateRA,
  title={N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers.},
  author={Helena Decker and Sofia J{\"u}rgensen and Martin F Adrover and Jordano Brito-Moreira and Theresa R. Bomfim and William L. Klein and Alberto Luis Epstein and Fernanda G De Felice and Diana Alicia Jerusalinsky and S{\'e}rgio T. Ferreira},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 6},
  pages={1520-9}
}
Soluble amyloid-β peptide (Aβ) oligomers, known to accumulate in Alzheimer's disease brains, target excitatory post-synaptic terminals. This is thought to trigger synapse deterioration, a mechanism possibly underlying memory loss in early stage Alzheimer's disease. A major unknown is the identity of the receptor(s) targeted by oligomers at synapses. Because oligomers have been shown to interfere with N-methyl-d-aspartate receptor (NMDAR) function and trafficking, we hypothesized that NMDARs… CONTINUE READING
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