N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease.

@article{Waxman2005NmethylDaspartateRS,
  title={N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease.},
  author={Elisa A. Waxman and David R Lynch},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year={2005},
  volume={11 1},
  pages={37-49}
}
N-methyl-D-aspartate (NMDA) receptors are the major mediator of excitotoxicity. Although physiological activation of the NMDA receptor is necessary for cell survival, overactivation is a signal for cell death. Several pathways are activated through NMDA receptor stimulation, most of which can contribute to excitotoxicity. These include events leading to mitochondrial dysfunction, activation of calcium-dependent enzymes, and activation of mitogen-activated protein kinase pathways. Understanding… CONTINUE READING

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