N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey.

@article{Walln1987NmethylDaspartateRI,
  title={N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey.},
  author={Peter Wall{\'e}n and Sten Grillner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1987},
  volume={7 9},
  pages={2745-55}
}
Bath application of N-methyl-aspartate induces fictive locomotor activity in the isolated spinal cord preparation of the lamprey, as well as TTX-resistant membrane potential oscillations in many individual neurons. This inherent oscillatory activity is shown to depend on a specific activation of N-methyl-D-aspartate (NMDA) receptors. This activation initiates voltage-dependent, magnesium-requiring membrane potential bistability, presumably due to a development of a region of negative slope… CONTINUE READING
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