N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia.

@article{Anticevic2015NmethylDaspartateRA,
  title={N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia.},
  author={Alan Anticevic and Philip Corlett and Michael W. Cole and Aleksandar Savi{\'c} and Mark G Gancsos and Yanqing Tang and Grega Repov{\vs} and John D Murray and Naomi R. Driesen and Peter T. Morgan and Ke Xu and Fei Wang and John H. Krystal},
  journal={Biological psychiatry},
  year={2015},
  volume={77 6},
  pages={569-80}
}
BACKGROUND Prefrontal cortex (PFC) function contributes to schizophrenia onset and progression. However, little is known about neural mechanisms behind PFC functional alterations along illness stages. Recent pharmacologic studies indicate that glutamate dysfunction may produce increased functional connectivity. However, pharmacologic models of schizophrenia overlook effects of illness progression on PFC function. This study compared N-methyl-D-aspartate glutamate receptor (NMDAR) antagonist… CONTINUE READING