N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam.

@article{Rice1999NmethylDaspartateRA,
  title={N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam.},
  author={Ann C. Rice and Robert J Delorenzo},
  journal={Neuroscience},
  year={1999},
  volume={93 1},
  pages={
          117-23
        }
}
Status epilepticus, prolonged intermittent or continuous seizure activity lasting 30 min or longer, is associated with high morbidity and mortality. The longer a seizure persists, the more refractory to treatment it becomes. The pilocarpine model of status epilepticus in rodents develops refractoriness to many first-line treatments as seizure duration increases, rendering it a good model to study refractory status epilepticus. This study was initiated to study the development of refractoriness… CONTINUE READING

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