N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets.

@article{Domoki2002NmethylDaspartateinducedVI,
  title={N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets.},
  author={Ferenc Domoki and James V Perciaccante and Katsuyoshi Shimizu and Michelle Puskar and David William Busija and Ferenc Bari},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 4},
  pages={H1404-9}
}
N-methyl-D-aspartate (NMDA) elicits pial arteriolar dilation that has been associated with neuronal nitric oxide (NO) production. However, endothelial factors or glial P-450 epoxygenase products may play a role. We tested whether NMDA-induced pial vasodilation 1) primarily involves NO diffusion from the parenchyma to the surface arterioles, 2) involves intact endothelial function, and 3) involves a miconazole-sensitive component. Arteriolar diameters were determined using closed cranial window… CONTINUE READING

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