N-methyl-D-aspartate glutamate receptor antagonists and the promise of rapid-acting antidepressants.


T HE EXCITING FINDings reported by Diazgranados and her collagues regarding the antidepressant efficacy of the uncompetitive Nmethyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine in depressed patients with bipolar disorder add to the emerging interest in rapid-acting antidepressants (RAAs). Their article describes robust, clinically relevant, and rapid alleviation of depression symptoms in patients with bipolar disorder that persists far beyond the presence of the drug in the body. Ketamine has a terminal half-life of approximately 3 hours. Yet after 2 days, or 16 half-lives, of ketamine, the effect size of its antidepressant effects was large (0.8). Impressively, at 2 weeks

DOI: 10.1001/archgenpsychiatry.2010.138


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@article{Krystal2010NmethylDaspartateGR, title={N-methyl-D-aspartate glutamate receptor antagonists and the promise of rapid-acting antidepressants.}, author={John Harrison Krystal}, journal={Archives of general psychiatry}, year={2010}, volume={67 11}, pages={1110-1} }