N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease.

  title={N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease.},
  author={J Timothy Greenamyre and Cathy O'Brien},
  journal={Archives of neurology},
  volume={48 9},
Current long-term treatment of Parkinson's disease is inadequate, and improved symptomatic and neuroprotective therapies are needed. Recent interest has focused on the use of antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in Parkinson's disease. Abnormally increased activity of the subthalamic nucleus is postulated to play a central pathophysiological role in the signs of Parkinson's disease, and NMDA antagonists may provide a means of decreasing this activity… CONTINUE READING
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