N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism.

  title={N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism.},
  author={Roger Simon and K Shiraishi},
  journal={Annals of neurology},
  volume={27 6},
Pharmacological inhibition of cell excitation during focal ischemia was studied in the rat middle cerebral artery occlusion model. The potent and selective N-methyl-D-aspartate antagonist CGS 19755, administered 5 minutes prior to or 5 minutes following permanent middle cerebral artery occlusion, caused a substantial decrease in infarct size, which was associated with reduction of postischemic cerebral glucose hypermetabolism. These data support a role for excitation-induced hypermetabolism in… CONTINUE READING


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