N-methyl-D-aspartate and sigma-ligands change the production of interleukins 8 and 10 in lymphocytes through modulation of the NMDA glutamate receptor.

@article{Kvaratskhelia2009NmethylDaspartateAS,
  title={N-methyl-D-aspartate and sigma-ligands change the production of interleukins 8 and 10 in lymphocytes through modulation of the NMDA glutamate receptor.},
  author={Eka Kvaratskhelia and Ekaterine Maisuradze and Nino G Dabrundashvili and Nino Natsvlishvili and Elene I Zhuravliova and David G. Mikeladze},
  journal={Neuroimmunomodulation},
  year={2009},
  volume={16 3},
  pages={201-7}
}
Human T lymphocytes express both ionotropic and metabotropic glutamate receptors that control immune responses, cell activation, maturation and death. In this study, we examined the effect of N-methyl-D-aspartate (NMDA) and sigma1-receptor ligands on the secretion of the proinflammatory chemokine interleukin 8 (IL-8) and the anti-inflammatory cytokine interleukin 10 (IL-10) in human leukemia Jurkat cells and peripheral blood lymphocytes (PBLs). We have shown that NMDA increased IL-8 and… CONTINUE READING

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New insights into the molecular mechanism of interleukin - 10 - mediated immunosuppression

  • G Grütz
  • J Leukoc Biol
  • 2005

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