N-methyl-D-aspartate activates different channels than do kainate and quisqualate.

  title={N-methyl-D-aspartate activates different channels than do kainate and quisqualate.},
  author={Juan Lerma and Leslie Kushner and R Suzanne Zukin and Michael V. L. Bennett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 6},
In the mammalian central nervous system, the excitatory amino acid transmitter L-glutamate activates three pharmacologically distinguishable receptors, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate receptors. The present paper addresses the issue of whether these three receptors operate independent channels or whether they share channels that may have several conductance substates. The Xenopus oocyte provides a system for expression of exogenous mRNAs that permits detailed study of… CONTINUE READING

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