N-linked peptidoresorc[4]arene-based receptors as noncompetitive inhibitors for α-chymotrypsin.

This paper deals with the design, synthesis, and evaluation of a new series of receptors for protein surface recognition. The design of these agents is based around the attachment of four constrained dipeptide chains onto a central resorc[4]arene scaffold. By varying the sequence, nature, and stereochemistry of the chains we prepared anionically… (More)