N-linked glycans of Bombyx mori nucleopolyhedrovirus fibroblast growth factor are crucial for its secretion.

@article{Katsuma2006NlinkedGO,
  title={N-linked glycans of Bombyx mori nucleopolyhedrovirus fibroblast growth factor are crucial for its secretion.},
  author={Susumu Katsuma and Takaaki Daimon and Satoshi Horie and Michihiro Kobayashi and Toru Shimada},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={350 4},
  pages={1069-75}
}
Bombyx mori nucleopolyhedrovirus (BmNPV) fibroblast growth factor (BmFGF) is a glycosylated protein that is efficiently secreted into the medium. Here, we constructed mutant NPVs expressing His-tagged wild-type (wt) or mutant BmFGFs and showed that the two residues, asparagine 44 and 171, are the glycosylation sites of BmFGF. Also, removal of N-linked glycans from BmFGF resulted in almost complete inhibition of the secretion into the medium, suggesting that N-linked glycans of BmFGF are… CONTINUE READING

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