N-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality control.

@article{Moremen2006NlinkedGR,
  title={N-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality control.},
  author={Kelley W Moremen and Maurizio Molinari},
  journal={Current opinion in structural biology},
  year={2006},
  volume={16 5},
  pages={592-9}
}
Nascent polypeptides emerging into the lumen of the endoplasmic reticulum (ER) are N-glycosylated on asparagines in Asn-Xxx-Ser/Thr motifs. Processing of the core oligosaccharide eventually determines the fate of the associated polypeptide by regulating entry into and retention by the calnexin chaperone system, or extraction from the ER folding environment for disposal. Recent advances have shown that at least two N-glycans are necessary for protein access to the calnexin chaperone system and… CONTINUE READING

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