N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.

@article{Wang2015NhydroxylationO4,
  title={N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.},
  author={Shuang Wang and Kim S. Sugamori and Aveline Y. W. Tung and John Peter McPherson and Denis M. Grant},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={144 2},
  pages={393-405}
}
4-Aminobiphenyl (ABP) is a trace component of cigarette smoke and hair dyes, a suspected human carcinogen and a potent rodent liver carcinogen. Postnatal exposure of mice to ABP results in a higher incidence of liver tumors in males than in females, paralleling the sex difference in human liver cancer incidence. A traditional model of ABP tumorigenesis involves initial CYP1A2-mediated N-hydroxylation, which eventually leads to production of mutagenic ABP-DNA adducts that initiate tumor growth… CONTINUE READING

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