N-glycosylation sites on the nicotinic ACh receptor subunits regulate receptor channel desensitization and conductance.

@article{Nishizaki2003NglycosylationSO,
  title={N-glycosylation sites on the nicotinic ACh receptor subunits regulate receptor channel desensitization and conductance.},
  author={Tomoyuki Nishizaki},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={114 2},
  pages={172-6}
}
The present study investigated the effects of N-glycosylation sites on Torpedo acetylcholine (ACh) receptors expressed in Xenopus oocytes by monitoring whole-cell membrane currents and single-channel currents from excised patches. Receptors with the mutant subunit at the asparagine residue on the conserved N-glycosylation site (mbetaN141D, mgammaN141D, or mdeltaN143D) or the serine/threonine residue (mbetaT143A, mgammaS143A, or mdeltaS145A) delayed the rate of current decay as compared with… CONTINUE READING
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