N-glycosylation is required for binding of murine pregnancy-specific glycoproteins 17 and 19 to the receptor CD9.

@article{Ha2008NglycosylationIR,
  title={N-glycosylation is required for binding of murine pregnancy-specific glycoproteins 17 and 19 to the receptor CD9.},
  author={Cam T. Ha and Roseann Waterhouse and James Warren and Wolfgang Zimmermann and Gabriela S. Dveksler},
  journal={American journal of reproductive immunology},
  year={2008},
  volume={59 3},
  pages={251-8}
}
PROBLEM Murine pregnancy-specific glycoproteins (PSGs) are encoded by 17 different genes. Different family members have different expression levels at different stages of embryonic development. It is currently unknown whether all members of this family of placentally secreted proteins have the same function and bind to the same receptor. Furthermore, the requirement of post-translational modifications for the activity of these highly glycosylated proteins remains undetermined. METHOD OF STUDY… CONTINUE READING

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