N-glycosylation as a biochemical basis for virulence in Leishmania mexicana amazonensis.

@article{Kink1988NglycosylationAA,
  title={N-glycosylation as a biochemical basis for virulence in Leishmania mexicana amazonensis.},
  author={John Alan Kink and Kwang Poo Chang},
  journal={Molecular and biochemical parasitology},
  year={1988},
  volume={27 2-3},
  pages={
          181-90
        }
}
Promastigotes of Leishmania mexicana amazonensis grown in vitro under different conditions showed variable degrees of virulence, as determined quantitatively by the size of the lesions and the number of intracellular parasites produced in mice and in cultured macrophages, respectively. Promastigotes newly transformed from amastigotes gave the highest degree of virulence, which decreased progressively with periods of their continuous in vitro cultivation. This loss of virulence was prevented by… CONTINUE READING
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