N-glycosylation alters cadherin-mediated intercellular binding kinetics.

Abstract

We present direct evidence that the N-glycosylation state of neural cadherin impacts the intrinsic kinetics of cadherin-mediated intercellular binding. Micropipette manipulation measurements quantified the effect of N-glycosylation mutations on intercellular binding dynamics. The wild-type protein exhibits a two-stage binding process in which a fast… (More)
DOI: 10.1242/jcs.101147

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