N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible.

@article{Heiskanen2007NglycolylneuraminicAX,
  title={N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible.},
  author={Annamari Heiskanen and Tero Satomaa and Sari Tiitinen and Anita Laitinen and Sirkka Mannelin and Ulla Impola and Milla Mikkola and Cia Olsson and Halina Miller-Podraza and Maria Blomqvist and Anne Olonen and Hanna M E Salo and Petri Lehenkari and Timo Tuuri and Timo Otonkoski and Jari Natunen and Juhani O. Saarinen and Jarmo Laine},
  journal={Stem cells},
  year={2007},
  volume={25 1},
  pages={
          197-202
        }
}
Human embryonic and mesenchymal stem cell therapies may offer significant benefit to a large number of patients. Recently, however, human embryonic stem cell lines cultured on mouse feeder cells were reported to be contaminated by the xeno-carbohydrate N-glycolylneuraminic acid (Neu5Gc) and considered potentially unfit for human therapy. To determine the extent of the problem of Neu5Gc contamination for the development of stem cell therapies, we investigated whether it also occurs in cells… CONTINUE READING
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