N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.

Abstract

BACKGROUND Wild-type pigs express several carbohydrate moieties on their cell surfaces that differ from those expressed by humans. This difference in profile leads to pig tissue cell recognition of human blood cells causing sequestration, in addition to antibody-mediated xenograft injury. One such carbohydrate is N-glycolylneuraminic acid (Neu5Gc), a sialic… (More)
DOI: 10.1111/xen.12339

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@article{Cimeno2017NglycolylneuraminicAK, title={N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.}, author={Arielle Cimeno and Wessam Hassanein and Beth M French and Jessica M Powell and Lars Burdorf and Olga Goloubeva and Xiangfei Cheng and Dawn M Parsell and Jagdeece J Ramsoondar and Kasinath Kuravi and Todd D. Vaught and Mehmet C. Uluer and Emily Redding and Natalie A O'Neill and Christopher T Laird and Alena V. Hershfeld and Ivan I Tatarov and Kathryn A Thomas and David L. Ayares and Agnes M Azimzadeh and Richard N Pierson and Rolf N. Barth and John C LaMattina}, journal={Xenotransplantation}, year={2017}, volume={24 6} }