N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.

@article{Hedlund2007NglycolylneuraminicAD,
  title={N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.},
  author={Maria Hedlund and Pam Tangvoranuntakul and Hiromu Takematsu and Jeffrey M. Long and Gary D. Housley and Yasunori Kozutsumi and Akemi Suzuki and Anthony Wynshaw-Boris and Allen F Ryan and Richard L Gallo and Nissi M. Varki and Ajit Varki},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 12},
  pages={4340-6}
}
Humans and chimpanzees share >99% identity in most proteins. One rare difference is a human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the sialic acid N-glycolylneuraminic acid (Neu5Gc). Since Neu5Gc is prominent on most chimpanzee cell surfaces, this mutation could have affected multiple systems. However, Neu5Gc is found in human cancers and fetuses and in trace amounts in normal human tissues, suggesting an alternate biosynthetic pathway. We inactivated… CONTINUE READING