Corpus ID: 3255573

N-glucuronidation of benzidine and its metabolites. Role in bladder cancer.

@article{Zenser1998NglucuronidationOB,
  title={N-glucuronidation of benzidine and its metabolites. Role in bladder cancer.},
  author={T. Zenser and V. Lakshmi and B. Davis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 9},
  pages={
          856-9
        }
}
Workers exposed to high levels of benzidine have a 100-fold increased incidence of bladder cancer. This review evaluates the overall metabolism of benzidine to determine pathways important to initiation of bladder cancer. Upon incubation of benzidine with liver slices from rats, dogs, and humans, different proportions of this diamine were N-acetylated and N-glucuronidated. With dogs, a non-acetylator species, N-glucuronidation was the major pathway. In contrast, little glucuronidation was… Expand
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