N-formylmethionyl peptides as chemoattractants for leucocytes.

  title={N-formylmethionyl peptides as chemoattractants for leucocytes.},
  author={Elliott Schiffmann and Barbara A. Corcoran and Sharon M. Wahl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={72 3},
Leucocytes such as neutrophils are attracted by N-formylmethionine, but not by methionine. Di- and tripeptides containing formylmethionine are strong attractants for both neutrophils and macrophages, whereas the corresponding nonacylated compounds are not chemotactic. The formylated peptides may be related to an incompletely characterized chemotactic material normally produced by bacteria which attract the same animal cells. 

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