N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) administration for studies of 5-HT1A receptor binding site inactivation and turnover.

@article{Keck1997Nethoxycarbonyl2ethoxy12dihydroquinol,
  title={N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) administration for studies of 5-HT1A receptor binding site inactivation and turnover.},
  author={Barbara Keck and Joan M. Lakoski},
  journal={Brain research. Brain research protocols},
  year={1997},
  volume={1 4},
  pages={364-70}
}
Alterations in the function of the neurotransmitter serotonin (5-HT) have been implicated in several neurobehavioral disorders, including depression, anxiety as well as a well-known disorder of aging, Alzheimer's disease. Age-dependent changes in the serotonergic system include a loss of 5-HT-containing fibers in brain areas which contain high levels of 5-HT1A receptors. Other changes with aging include decreased 5-HT levels, increases in monoamine oxidase (the major 5-HT degrading enzyme), and… CONTINUE READING