N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.

@article{Ahmed1997NepsiloncarboxyethyllysineAP,
  title={N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.},
  author={M Uddin Ahmed and E Brinkmann Frye and Thorsten P. Degenhardt and Suzanne R. Thorpe and John W. Baynes},
  journal={The Biochemical journal},
  year={1997},
  volume={324 ( Pt 2)},
  pages={
          565-70
        }
}
Advanced glycation end-products and glycoxidation products, such as Nepsilon-(carboxymethyl)lysine (CML) and pentosidine, accumulate in long-lived tissue proteins with age and are implicated in the aging of tissue proteins and in the development of pathology in diabetes, atherosclerosis and other diseases. In this paper we describe a new advanced glycation end-product, Nepsilon-(carboxyethyl)lysine (CEL), which is formed during the reaction of methylglyoxal with lysine residues in model… Expand

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