• Corpus ID: 20005224

N-dephenylation of CERM 3517 (mociprazine) in beagle dogs. A mass spectrometric determination.

@article{Pognat1986NdephenylationOC,
  title={N-dephenylation of CERM 3517 (mociprazine) in beagle dogs. A mass spectrometric determination.},
  author={J. F. Pognat and A Enreille and Jean Louis Chabard and Norbert Busch and J. A. Berger},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1986},
  volume={14 2},
  pages={
          147-54
        }
}
  • J. Pognat, A. Enreille, J. Berger
  • Published 1 March 1986
  • Chemistry, Biology
  • Drug metabolism and disposition: the biological fate of chemicals
CERM 3517 (mociprazine), a new antiemetic compound, was administered orally at 10 mg/kg twice a day for 4 days to six Beagle dogs in order to identify the major metabolite. Mass spectrometric comparison of this metabolite and a synthesized reference compound (CERM 4082) showed that both had identical structures. The metabolite originated from cleavage of the aromatic moiety. After iv administration of CERM 3517 (0.9 mg/kg) and CERM 4082 (0.6 mg/kg) to five beagle dogs, 13% and 56% of the dose… 
N-Dephenylated and N-phenyl urinary metabolites of mociprazine (CERM 3517) in beagle dogs after oral administration. A mass spectrometric determination
TLDR
The role of the para-hydroxyl intermediate was proved to be essential for the N-dephenylation after intravenous administration of meta- and para-Hydroxylated derivatives of CERM 3517 to five beagle dogs.
Biotransformation study of para-substituted phenylpiperazines in beagle dogs by gas chromatography-mass spectrometry.
TLDR
Beagle dogs were treated orally with para-chloro-, para-fluoro- and para-methyl-phenylpiperazine derivatives, and urine was collected for 72 h after treatment and two kinds of hydroxylated metabolites were found.