N-demethylation and N-oxidation of imipramine by rat and pig liver microsomes.

@article{Gigon1971NdemethylationAN,
  title={N-demethylation and N-oxidation of imipramine by rat and pig liver microsomes.},
  author={Philippe Gigon and MARCEL H. Bickel},
  journal={Biochemical pharmacology},
  year={1971},
  volume={20 8},
  pages={
          1921-31
        }
}
Metabolic interconversions and binding of imipramine, imipramine-N-oxide, and desmethylimipramine in rat liver slices.
  • M. Bickel, P. Gigon
  • Chemistry, Biology
    Xenobiotica; the fate of foreign compounds in biological systems
  • 1971
TLDR
More DMI seems to be formed from IPNO by secondary microsomal metabolism of imipramine than by direct N-oxide demethylation, which is more than double that of IPNO.
N-oxide formation and related reactions in drug metabolism.
  • M. Bickel
  • Chemistry, Biology
    Xenobiotica; the fate of foreign compounds in biological systems
  • 1971
TLDR
It could be shown that tertiary amine dealkylation and N-oxidation are catalyzed by microsomal enzymes only, whereas N-oxide dealkYLation and reduction occur only in extra-microsomal compartments.
The effect of antidepressants on ethylmorphine and imipramine N‐demethylation in rat liver microsomes
TLDR
It can be assumed that prolonged administration of the drugs investigated has two different effects on the oxygenase systems in rat liver microsomes: on the one hand they stimulate the cytochrome P450 oxygenase system involved in ethylmorphine demethylation and, on the other, they inhibit the other microsomal oxygenaseSystem involved in dem methylation of imipramine.
The microsomal N‐oxidation of phentermine
TLDR
The metabolic characteristics and kinetic behaviour of the microsomal N‐oxidation of Ia supported a recently proposed mechanism explaining the independent formation of Ib and Ic from a common precursor resulting from metabolic N‐oxygenated metabolites.
Effect of diphenylhydantoin on the biotransformation and biliary excretion of imipramine in rats.
  • P. Gigon
  • Medicine, Biology
    Xenobiotica; the fate of foreign compounds in biological systems
  • 1975
TLDR
Administration of diphenylhydantoin does not significantly alter the concentration of imipramine plus metabolites in plasma, liver, lung and brain measured at five consecutive 30 min periods after dosage.
Microsomal N-hydroxylation of dibenzylamine.
  • A. Beckett, G. Gibson
  • Biology, Chemistry
    Xenobiotica; the fate of foreign compounds in biological systems
  • 1975
TLDR
The properties of the rabbit liver microsomal enzyme system catalysing the formation of N,N-dibenzylhydroxylamine as the major metabolite of dibenzylamine have been investigated and the effect of various metabolic inhibitors on the N-oxidation process in vitro is investigated.
Alterations induced in distribution and in vivo metabolism of imipramine by pregnenolone-16alpha-carbonitrile.
TLDR
The protective action of I was associated with diminished organ levels of imipramine (catatoxic mechanism), and the relationship between brain and plasma imipramsine concentrations remained unaltered.
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