N-carbamoyl-alpha-amino acids rather than free alpha-amino acids formation in the primitive hydrosphere: a novel proposal for the emergence of prebiotic peptides.

@article{Taillades1998NcarbamoylalphaaminoAR,
  title={N-carbamoyl-alpha-amino acids rather than free alpha-amino acids formation in the primitive hydrosphere: a novel proposal for the emergence of prebiotic peptides.},
  author={Jacques Taillades and Isabelle Beuzelin and Laurence Garrel and Vlado Tabacik and Catherine Bied and Auguste Commeyras},
  journal={Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life},
  year={1998},
  volume={28 1},
  pages={61-77}
}
Our previous kinetic and thermodynamic studies upon the reactional system HCHO/HCN/NH3 in aqueous solutions are completed. In the assumed prebiotic conditions of the primitive earth ([HCHO] and [HCN] near 1 g L-1, T = 25 degrees C, pH = 8, [NH3] very low), this system leads to 99.9% of alpha-hydroxyacetonitrile and 0.1% of alpha-aminoacetonitrile (precursor of the alpha-amino acid). The classical base-catalyzed hydration of nitriles, slow and not selective, can not modify significantly this… CONTINUE READING