N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation.

@article{Hulit2007NcadherinSP,
  title={N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation.},
  author={James Hulit and Kimita Suyama and Su Yun Chung and Rinat Keren and Georgia Agiostratidou and Weisong Shan and Xinyuan Dong and Terence M. Williams and Michael Phillip Lisanti and Karen E. Knudsen and Rachel B. Hazan},
  journal={Cancer research},
  year={2007},
  volume={67 7},
  pages={3106-16}
}
N-cadherin is up-regulated in aggressive breast carcinomas, but its mechanism of action in vivo remains unknown. Transgenic mice coexpressing N-cadherin and polyomavirus middle T antigen (PyVmT) in the mammary epithelium displayed increased pulmonary metastasis, with no differences in tumor onset or growth relative to control PyVmT mice. PyVmT-N-cadherin tumors contained higher levels of phosphorylated extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK… CONTINUE READING