N-cadherin promotes adhesion between invasive breast cancer cells and the stroma.

@article{Hazan1997NcadherinPA,
  title={N-cadherin promotes adhesion between invasive breast cancer cells and the stroma.},
  author={Rachel B. Hazan and Lu Kang and Brian P. Whooley and Patrick Ivan Borgen},
  journal={Cell adhesion and communication},
  year={1997},
  volume={4 6},
  pages={
          399-411
        }
}
Calcium-dependent cell adhesion molecules (cadherins) are involved in maintaining the epithelial structure of a number of tissues including the mammary gland. In breast and other tumor types, loss of E-cadherin expression has been seen in high grade tumors and correlates with increased invasiveness. Here we show high levels of expression of N-cadherin in the most invasive breast cancer cell lines which was inversely correlated with their expression of E-cadherin. A stromal cell line also… CONTINUE READING
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