N-cadherin prodomain processing regulates synaptogenesis.

@article{Reines2012NcadherinPP,
  title={N-cadherin prodomain processing regulates synaptogenesis.},
  author={Analia G Reines and Louis-Philippe Bernier and Robyn L McAdam and Wiam Belkaid and Weisong Shan and Alexander Walter Koch and Philippe S{\'e}gu{\'e}la and David R. Colman and Ajit Singh Dhaunchak},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 18},
  pages={
          6323-34
        }
}
Classical cadherins, which are adhesion molecules functioning at the CNS synapse, are synthesized as adhesively inactive precursor proteins in the endoplasmic reticulum (ER). Signal sequence and prodomain cleavage in the ER and Golgi apparatus, respectively, activates their adhesive properties. Here, we provide the first evidence for sorting of nonadhesive precursor N-cadherin (ProN) to the neuronal surface, where it coexists with adhesively competent mature N-cadherin (N-cad), generating a… CONTINUE READING

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