N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.

  title={N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.},
  author={Frances M Platt and G R Neises and Raymond A. Dwek and Terry D. Butters},
  journal={The Journal of biological chemistry},
  volume={269 11},
The imino sugar deoxynojirimycin and its alkylated derivatives are inhibitors of the N-linked oligosaccharide processing enzymes alpha-glucosidase I and II. These compounds are glucose analogues and have the potential to inhibit both glucosidases and glucosyltransferases. However, to date there has been no report of deoxynojirimycin or similar analogues inhibiting a mammalian glucosyltransferase. We have investigated the effects of deoxynojirimycin and its alkylated derivatives on the… CONTINUE READING


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