• Corpus ID: 8011258

N-body Information Theory (NbIT) Analysis of Rigid-Body Dynamics in Intracellular Loop 2 of the 5-HT2A Receptor

  title={N-body Information Theory (NbIT) Analysis of Rigid-Body Dynamics in Intracellular Loop 2 of the 5-HT2A Receptor},
  author={Michael V. LeVine and Jose Manuel Perez-Aguilar and Harel Weinstein},
  booktitle={International Work-Conference on Bioinformatics and Biomedical Engineering},
Rigid-body motions of protein secondary structure are often impli- cated in mechanisms of protein function. In GPCRs, evidence suggests that in- tracellular loop 2 (IL2) contains a segment characterized as a helix when the ac- tivated receptor triggers downstream signaling. However, neither experimental nor computational methods are readily available to assess quantitatively the de- gree of collective motions in such secondary structure motifs of proteins. Here we describe a new element of our… 

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